17-20 % of the population may have this newly recognized syndrome. There is more diagnosis in Europe than USA but it is worth knowing about especially if you present with MCAS listed symptoms. A mast cell is a single cell that can behave, for example, as an immune cell, an endocrine cell or even as a sensorial neuron. Due to this, mast cells can significantly influence inflammation, tissue remodelling, host defence and homeostasis.
It is a form of white blood cell related to basophils. Yet they are individual cells and not the same or copies. Mast cells are found in most tissue of the body – they are in higher concentration where they are in close contact of the external environment – such as skin, uterus, airways and intestines.
MCAS is where there is an inappropriate release of mast cell mediators
It does not mean there are more mast cells.
Mast cell mediators can be histamine, heparin, serotonin, IL-6, IL-1, TNF alpha, interferon-Y, TGF- B, chymase, tryptase
Andrographis – interferes with T cell activation decreasing autoimmune response and has antimicrobial properties. Decreases T cell response/ decreased Th2. Decreased IL- 10, TNFa so decreases inflammation
If histamine production is increased due to mast cell production it is worth considering a person’s current orthodox medications. This is a list of orthodox medications that can influence histamine levels. If a person with this condition is on these then it could be making the condition more complicated. If concerned discuss with your medical doctor.
While eliminating high-histamine foods from your diet is a great idea, diet alone is NOT a long term correction. It is a multifactorial approach that helps the most. Treating the triggers is a good start.
• Avoid or reduce eating canned foods and processed or ready-made meals.
• Avoid or reduce eating ripened and fermented foods (older cheeses, alcoholic drinks, products containing yeast)
• Histamine levels in foods vary, depending on how ripe, matured or hygienic the foods.
• As much as it is possible, only buy and eat fresh products.
• Don’t allow foods to linger outside the refrigerator – especially meat products
AVOID or LIMIT FOODS HIGH IN HISTAMINES
• Alcohol – esp. wine, champagne and beer.
• Pickled or canned foods – sauerkraut, pickles, mayonnaise, olives
• Matured cheeses, including goat cheese
• Cured/Smoked meat products – salami, ham, sausages, bacon, salami, pepperoni, lunch meats and hot dogs
• Various species of fish: mackerel, mahi-mahi, tuna, anchovies, sardines
• Beans and pulses – chickpeas, soy beans, peanuts
• Nuts – walnuts, cashew nuts, cashews, and peanuts
• Chocolates and other cocoa based products
• Avocados, eggplant, spinach, and tomatoes
• Most citric fruits, apricots, prunes, dates, figs, raisins
• Wheat based products
• Processed and Ready-made meals
• Salty snacks, sweets with preservatives and artificial colourings